Single dose rasburicase in the management of tumor lysis syndrome in childhood acute lymphoblastic leukemia: A case series
نویسندگان
چکیده
منابع مشابه
The Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملAcute tumor lysis syndrome secondary to a single-dose methylprednisolone in acute lymphoblastic leukemia.
There are very few reports in the English literature regarding cases with acute lymphoblastic leukemia (ALL) who developed acute tumor lysis syndrome (ATLS) after a single dose of steroid at the beginning of the chemotherapy [1-6]. Herein, we present a child with T-cell ALL who developed ATLS after methylprednisolone (2 mg/kg) therapy. A seven-year-old, previously healthy girl was admitted to o...
متن کاملthe efficacy of single dose rasburicase in prevention or treatment of tumor lysis syndrome in children
background: tumor lysis syndrome (tls) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. the role of rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of tls has been demonstrated in recent years. we aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملSingle-dose rasburicase 6 mg in the management of tumor lysis syndrome in adults.
Rasburicase is currently approved at a dosage of 0.15-0.2 mg/kg once/day for 5 days in pediatric patients with cancer to lower plasma uric acid concentrations and manage tumor lysis syndrome (TLS). Information on rasburicase dosing in adults is limited, with some data on using rasburicase as a single dose instead of multiple daily doses. Therefore, we evaluated the efficacy of a single dose of ...
متن کاملIdentification of children with acute lymphoblastic leukemia at low risk for tumor lysis syndrome
Background and Objective: Tumor lysis syndrome (TLS) could occur before, during or after the initiation of chemotherapy in patients with cancers especially those with hematologic malignancies. This study was designed to determine the prevalence and predictors of TLS in children with Acute Lymphoblastic Lymphoma (ALL) and to develop a sensitive prediction rule to identify patients at low risk of...
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ژورنال
عنوان ژورنال: Indian Journal of Nephrology
سال: 2015
ISSN: 0971-4065
DOI: 10.4103/0971-4065.139092